Department of Environmental Management and Toxicology

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Browsing Department of Environmental Management and Toxicology by Author "ELEMIKE, Elias Emeka"

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    ORIGINAL CONTRIBUTION Open Access Phytochemical screening, antioxidant and antimicrobial activities of Acalypha ciliata plant
    (Springer Open, 2016-06) ODEJA,Oluwakayode; OGWUCHE, Christiana Ene,; ELEMIKE, Elias Emeka; OBI, Grace
    Background: Phytochemical screening, antioxidant and antimicrobial activities of hexane, ethylacetate and methanol crude extracts of Acalypha ciliata plant was studied in this work. This plant according to folk medicine has been reported to be used for treatment of female sterility, dressing of sores and schistosomiasis. Methods: The preliminary screening of the various extracts was carried out using standard methods and the results revealed the presence of flavonoids, tannins, alkaloids, reducing sugar, anthraquinones, resins and glycosides. The antimicrobial screening was carried out using the following organisms; Staphylococcus aureus, Eshericha coli, Bacillus subtilis, Pseudomonas aeruguinosa, Salmonella typhi, Klebsiellae pneumoniae, Candida albicans, Aspergillus niger, Penicillium notatum and Rhizopus stolonifer. The free radical scavenging capacity using hydrogen peroxide was equally determined to evaluate the antioxidant activities of the extracts. Results: The result obtained showed that Acalypha ciliata extracts have interesting pharmacological active compounds and antimicrobial effects, and as such could be used in ethno medicine for treatment of bacterial infections and ailments. Conclusion: The extracts of Acalypha ciliata plant contains notable chemical compounds that are responsible for its antioxidant and antimicrobial activity. Further investigations on the chemical compositions and possible isolation of active ingredients would be carried out